Name: Bikinin
Price: 188.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Bikini is a strong activator of Brassinosteroid (BR) signaling [1] and an inhibitor of glycogen synthase kinase 3 proteins (GSK3) [2]. BRs are a group of polyhydroxylated steroid hormones implicated in multiple developmental processes, including stem elongation, leaf expansion, vascular development, seed germination, and resistance to biotic and abiotic stresses. Genetic defects in biosynthesis or perception of BRs resulted in dwarﬁsm, dark-green and curled leaves, reduced seed germination and fertility, and de-etiolation in the dark. [1]Bikinin is the ﬁrst nonsteroidal molecule to modulate the BR signaling cascade downstream of the BRI1 receptor. Bikinin directly targeted BIN2 and activated BR-dependent gene expression. Application of bikini partially restored the phenotype of the bri1 loss-of-function mutant and the bin2 gain-of-function mutant to wild-type. Bikinin clearly rescued the dwarﬁsm of the hypocotyls and the petioles of the bin2 gain-of-function mutant. Bikinin are fully rescuing the BR-related phenotypes of this mutation while having no effect on the auxin-related phenotypes. [1]Bikinin treatment also induced tracheary element differentiation in Nicotiana benthamiana leaf disks, this leaf-disk culture system may be applicable to different plant species. [2]
    
    [1]. De Rybel B, Audenaert D, Vert G et al. Chemical inhibition of a subset of Arabidopsis thaliana GSK3-like kinases activates brassinosteroid signaling. Chem Biol. 2009 Jun 26;16(6):594-604.
    [2]. Kondo Y, Fujita T, Sugiyama M, Fukuda H. A Novel System for Xylem Cell Differentiation in Arabidopsis thaliana. Mol Plant. 2014 Dec 13. pii: S1674-2052(14)00026-4.
- Properties
  - Alternative Name
    
    4-((5-bromopyridin-2-yl)amino)-4-oxobutanoic acid
    
    CAS Number
    
    188011-69-0
    
    Molecular Formula
    
    C9H9BrN2O3
    
    Molecular Weight
    
    273.08
    
    Appearance
    
    A solid
    
    Purity
    
    99.74%
    
    Solubility
    
    insoluble in H2O; ≥13.65 mg/mL in DMSO; ≥2.4 mg/mL in EtOH
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Vandenbussche F. "Rapid Detection of Hormonal Involvement in Light Responses." Methods Mol Biol. 2019;2026:201-213. PMID:31317415

Bikinin

Bikinin

Background

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