O-Methylsterigmatocystin - Amerigo Scientific

- Overview
  - O-Methylsterigmatocystin is a natural product formed via methylation of sterigmatocystin. O-Methylsterigmatocystin is a xanthone metabolite isolated from several species of Aspergillus and Chaetomium. It is a precursor to aflatoxin G1 and B1 and, while it is considered mutagenic, teratogenic and carcinogenic, it is less potent than the aflatoxins. Research on this metabolite has focused on its genetic and phenotypic relationship to aflatoxins. O-Methylsterigmatocystin can be used to study the aflatoxin biosynthetic pathway.
    O-Methylsterigmatocystin is soluble in DMSO and DMF, moderately soluble in ethanol and methanol, and practically insoluble in water.
    
    Please contact us at for specific academic pricing.
- Properties
  - CAS Number
    
    17878-69-2
    
    Molecular Formula
    
    C19H14O6
    
    Molecular Weight
    
    338.3
    
    Appearance
    
    Pale yellow solid
    
    Other Properties
    
    Source: Chaetomium
    Purity Level: >95% by HPLC
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Microbiology Applications: O-Methylsterigmatocystin is converted to aflatoxin B1(AFB1) via an oxidoreductase gene (ord1) in the last step of the aflatoxin biosynthetic pathway in A. flavux and A. parasiticus. The ord1 gene encodes a cytochrome P-450-type monooxygenase, and the gene has been assigned to a new P-450 gene family named CYP64. Results suggest that this gene is responsible for this complex and crucial step of the pathway that is unique to aflatoxigenic fungal species.

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