Name: NSC 405020
Price: 206.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    NSC-405020 is a novel small molecule inhibitor of membrane type-I matrix metalloproteinase (MT1-MMP) that specifically targets the hemopexin (PEX) domain rather than the catalytic domain of MT1-MMP with 50% inhibition concentration IC50 value larger than 100 μmol/L and does not inhibit the catalytic activity of MT1-MMP or MMP-2. NSC-405020 directly interacts with and binds to PEX in a vicinity of Met-328, Arg-330, Asp-376, Met-22 and Ser-470 of the druggable pocket in the full-length MT1-MMP structure, which affects the conformation and flexibility of blades I to IV of the β-propeller resulting in the decrease of the PEX-dependent homodimerization of cellular MT1-MMP. NSC-405020 dose not affect the ability of MT1-MMP to activate MMP-2 but its ability to degrade COL-I.
- Properties
  - Alternative Name
    
    NSC405020, NSC-405020; 3,4-dichloro-N-pentan-2-ylbenzamide
    
    CAS Number
    
    7497-07-6
    
    Molecular Formula
    
    C12H15Cl2NO
    
    Molecular Weight
    
    260.16
    
    Appearance
    
    A solid
    
    Purity
    
    99.13%
    
    Solubility
    
    insoluble in H2O; ≥11.4 mg/mL in DMSO; ≥96.4 mg/mL in EtOH
    
    Storage
    
    Store at RT
    
    * For Research Use Only
- Reference
  - 1. Patricia Llorente, Soraia Martins, et al. "Matrix Metalloproteinase 14 Mediates APP Proteolysis and Lysosomal Alterations Induced by Oxidative Stress in Human Neuronal Cells." Oxid Med Cell Longev. 2020 Nov 16;2020:5917187. PMID:33282112
    2. El Azzouzi K, Wiesner C, Linder S. "Metalloproteinase MT1-MMP islets act as memory devices for podosome reemergence." J Cell Biol. 2016 Apr 11;213(1):109-25. PMID:27069022