Name: NSC 319726
Price: 215.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    NSC 319726 is a reactivator of mutant p53 with IC50 value of 8nM [1].NSC 319726 belongs to the thiosemicarbazone family. In a mouse fibroblast cell line Balb/c 3T3, NSC 319726 shows greater inhibition of cell growth in cells expressing mutant p53 than in WT p53 control. NSC 319726 is also nontoxic to WI38 human fibroblasts (p53 WT). In three different ovarian carcinoma cell lines (TOV112D (p53R175H), OVCAR3 (p53R248W) and SKOV3 (p53-/-)), treatment of NSC 319726 results in an induction of apoptosis in the p53R175 mutant. NSC 319726 restores p53 function through inducing a conformation change of mutant p53 to a “WT-like” structure which can be recognized by the WT specific antibody. The inhibition of cell growth caused by NSC 319726 is also found in the TOV112D (p53R175H) xenografts when the dose of NSC 319726 is 1mg/kg. Furthermore, it is shown that zinc ion chelation and ROS changes are important for the apoptosis induced by NSC319726 [1].
    
    [1] Yu X, Vazquez A, Levine AJ, Carpizo DR. Allele-specific p53 mutant reactivation. Cancer Cell. 2012 May 15;21(5):614-25.
- Properties
  - Categories
    
    Reactivator of mutant p53
    
    Alternative Name
    
    N-[(Z)-1-pyridin-2-ylethylideneamino]azetidine-1-carbothioamide
    
    CAS Number
    
    71555-25-4
    
    Molecular Formula
    
    C11H14N4S
    
    Molecular Weight
    
    234.32
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; ≥3.43 mg/mL in EtOH with gentle warming and ultrasonic; ≥8.1 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC(=NNC(=S)N1CCC1)C2=CC=CC=N2
    
    * For Research Use Only