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Overview
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NNMT (Nicotinamide N-Methyltransferase) is an enzyme that catalyzes the methylation of nicotinamide (NA) and other pyridines using S-adenosyl-L-methionine (SAM) as the methyl group donor to produce SAH and 1-methylnicotinamide (MNA). NNMT plays a significant role in the regulation of metabolic pathways. It is expressed at high levels in several kinds of cancers, neurodegenerative diseases, obesity, and diabetes, indicating a potential target for therapy.
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