Name: Nitrofurantoin Sodium
Price: 310.00 USD

- Overview
  - Nitrofurantoin Sodium is the sodium salt of Nitrofurantoin, a broad-spectrum nitrofuran antibiotic that is used as a substrate for bacterial glycoprotein nitrofuran reductase. It is bacteriostatic against Gram-positive and Gram-negative bacteria. The compound has been found to have anti-cancer properties agains bladder cancer cells grown in vitro. The product can be used to study antibiotic resistance. Unlike Nitrofurantoin, Nitrofurantoin Sodium is highly soluble in water.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Upon entering a susceptible cell, Nitrofurantoin is activated by bacterial enzymes and targets ribosomes and nucleic acids which inhibit bacterial growth and leads to death of the bacterial cells. Resistance to Nitrofurantoin may be chromosomal or plasmid-mediated.
- Properties
  - CAS Number
    
    54-87-5
    
    Molecular Formula
    
    C8H5N4O5Na
    
    Molecular Weight
    
    260.14
    
    Solubility
    
    Freely soluble in water
    
    Other Properties
    
    Source: Synthetic
    Assay: >98%
    Purity Level: >98%
    
    Storage
    
    Ambient, <30°C; Protect from light.
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Nitrofurantoin is effective against Gram-positive and Gram-negative bacteria. Nitrofurantoin is effective against certain β-lactam resistant strains of VRE or vancomycin resistant Enterococcus; a glycopeptide antibiotic resistant "superbug."
    It is also used against Enterococci, Staphylococci, Streptococci, Corneybacteria, and E. coli.
    Most strains of Proteus spp. and Pseudomonas aeurginosa are resistant to Nitrofurantoin.
    
    Microbiology Applications: Nitrofurantoin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:
    E. coli 32 µg/mL - 64 µg/mL
    
    Eukaryotic Cell Culture Applications: Nitrofuranton is toxic to human WI-38 fibroblasts in culture. and antioxidants can mitigate effect. On a molecular basis, glutathione peroxidase was the most efficient at protection (Michiels and Remacle, 1988). Nitrofurantoin can alter the morphology, viability, and phagocytic activity of bovine mammary polymorphonuclear leukocytes in vitro, when added at 1 mg/ml (Nickerson et al, 1995).