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Overview
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Nikkomycin Z is a nucleoside-type antibiotic isolated from Steptomyces tendae. Nikkomycin Z has potent narrow spectrum activity against some fungi, including Rhizopus cirdinans, Colletrotrichum trifolii and Botrytis cinerea (MIC 1, 5 and 5 µg/mL) and Coccidioides species, entering clinical development for the treatment of coccidioidomycosis. Nikkomycin Z inhibits chitin synthesis. Nikkomycin Z in combination with caspofungin or micafungin is synergistic against Candida albicans and Candida parapsilosis biofilms. Nikkomycin A is active against Histoplasma capsulatum in vitro and in vivo.
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