NGEF Polyclonal Antibody (0.6 mg/mL) for WB, IHC, ELISA

NGEF Polyclonal Antibody (0.6 mg/mL) for WB, IHC, ELISA

Catalog Number:
A001508254RED
Mfr. No.:
RD252771A
Price:
$253
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      • Overview
        • Calculated MW: 82 kDa
          Observed MW: Refer to figures
          Gene Accession: BC031573

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          Background

          Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).

      • Properties
        • Host
          rabbit
          Antibody Type
          polyclonal
          Isotype
          IgG
          Reactivity
          human; mouse; rat
          Immunogen
          Fusion protein of human NGEF
          Purification
          Antigen affinity purification
          Conjugate
          Unconjugated
          Formulation
          PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
          Storage
          Store at -20°C. Avoid freeze-thaw cycles.
          Concentration
          0.6 mg/mL
          Antigen
          ARHGEF27, Eph receptor-interacting exchange protein, Eph-interacting exchange protein, EPHEXIN, Ephexin-1, Guanine nucleotide exchange factor, neuronal, Neuronal guanine nucleotide exchange factor, Ngef, NGEF (UniProt:Q8N5V2)

          * For reference only.

      • Applications
        • Application
          WB; IHC; ELISA
        • Application Dilutions
          WB 1:500-1:2000
          IHC 1:30-1:150
          ELISA 1:5000-1:10000

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