Neratinib Maleate

Neratinib Maleate

Catalog Number:
CR04341323TOK
Mfr. No.:
TOK-N068
Price:
$274
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      • Overview
        • Neratinib Maleate is the maleate salt form of Neratinib. Neratinib is a quinoline derivative. It acts as a tyrosine kinase inhibitor and has anticancer properties. Neratinib has shown benefit for HER2 positive breast cancer and non-small cell lung cancer.

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          Background

          Neratinib is a dual inhibitor of human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases with similar potency, and the inhibition is irreversible. It targets a cystine residue in the ATP binding pocket of the receptor. It can induce cell cycle arrest and decrease cell proliferation. The inhibition is irreversible.

      • Properties
        • CAS Number
          915942-22-2
          Molecular Formula
          C30H29ClN6O3 • C4H4O4
          Molecular Weight
          673.12
          Appearance
          Off-white to yellow powder
          Solubility
          DMSO with warming; very poorly soluble in ethanol; very poorly soluble in water
          Other Properties
          Source: Synthetic
          Purity Level: ≥99% (by HPLC)
          Storage
          -20°C

          * For research use only

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