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Overview
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Background
Necrostatin 2 (Nec-2) is a novel and potent necroptosis inhibitor with EC50 of 50 nM. It is an analog of necrostatin 1 (nec-1).
Necroptosis is a mechanism of necrotic cell death induced by apoptotic stimuli in the form of death domain receptor engagement by their respective ligands under conditions where apoptotic execution is prevented.
Nec-2 is efficacious in an animal model of ischemic stroke. Many Necroptosis inhibitor derivatives are designed for researchers. There is limited record for Nec-2, but some reports are related with other necrostatins. Nec-1, a small-molecule inhibitor of necroptosis, is also a selective allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP1 in vitro.
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