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Overview
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Background
Base modified ribonucleoside triphosphates, can be used in epigenetics research. N6-methyl ATP can substitute for ATP in some biological systems, and is a potent agonist for P2Y-purinoceptors in the guinea pig, taenia coli. In vitro studies showed that N6-methyl ATP substituted for ATP and supported cytoskeletal filament-driven translocation of motor proteins (dynein, kinesin and myosin). N6-methyl ATP is also a substrate for RNA polymerase and can be used for preparation of modified RNA.
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Overview