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Overview
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Background
IC50: 0.20 μM: inhibits inducible nitric oxide synthases (iNOS).IC50: 350 μM: blocks endothelial nitric oxide synthases (eNOS).N-Benzylacetamidine is a potent and selective inhibitor of iNOS compared to eNOS. NOS is essential to the formation of nitric oxide (NO) via the NADPH- and O2-dependent oxidation of L-arginine, which plays a role in regulating many pathological and physiological processes, including smooth muscle relaxation and neurotransmission. INOS contributes to immune response and inflammation while eNOS plays a vital role in regulating vascular tone.In vitro: N-Benzylacetamidine showed good iNOS and almost negligible eNOS inhibition in THP-1 cells, a human myelomonocytic leukemia cell line [1].In vivo: Up to now, in vivo study of N-Benzylacetamidine is still in the development stage.
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