(±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane

- Overview
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    Background
    
    (±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane, also known as trans-BTP Dioxolane, is a PAF receptor antagonist [1]. Platelet activating factor (PAF), a phospholipid mediator of inflammation, is secreted by several cell types including arterial endothelial cells, and can activate polymorphonuclear leucocytes and monocytes via specific cell surface receptors. PAF also stimulates the production of active oxygen species by human monocyte - derived macrophages. PAF play important roles in a variety of pathophysiological states including acute allergy, inflammation, asthma, gastrointestinal ulceration, and toxic shock [1]. (±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane is a PAF receptor antagonist. In the rabbit washed platelet assay, (±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane showed good competitive PAF antagonism with Ki value of 0.3 μM, whereas the cis-isomer was much less active.
- Properties
  - Categories
    
    PAF receptor antagonist
    
    Alternative Name
    
    trans-BTP Dioxolane; trans-(±)-2,4-bis(3,4,5-trimethoxyphenyl)-1,3-dioxolane
    
    CAS Number
    
    116673-45-1
    
    Molecular Formula
    
    C21H26O8
    
    Molecular Weight
    
    406.4
    
    Appearance
    
    A crystalline solid
    
    Solubility
    
    ≤35mg/ml in ethanol;50mg/ml in DMSO;50mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    COC1=CC([[email protected]]2O[[email protected]](C3=CC(OC)=C(OC)C(OC)=C3)OC2)=CC(OC)=C1OC
    
    * For Research Use Only

(±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane

(±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane

Background

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