Name: Myelin Basic Protein (87-99)
Price: 228.00 USD

- Overview
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    Background
    
    The basic protein is a major structural protein of the central nervous system myelin in which it constitutes 30% of the total protein.(1)
    T lymphocyte cell lines selected with whole MBP typically recognize only 1-3 immunodominant epitopes (Offner et al., 1987, 1988; Trotter et al., 1987: Bourdctte et al., 1988; McCarron and McFarlin, 1988) and these immunodominant MBP epitopes frequently are cncephalitogenic (Vandenbark et al., 1985b, 1989; Hashim et al., 1991). Thus, the identification of immunodominant MBP epitopes is likely to provide an in vitro method of identifying unrecognized enccphalitogenic epitopes of MBP. (2)
    Although the cause of multiple sclerosis (MS) is not known, a T cell-mediated autoimmune process has been postulated. Myelin basic protein (MBP) is a potential target antigen because it induces experimental allergic encephalomyelitis (EAE) in susceptible animals. Encephalitogenic epitopes of MBP differ among susceptible strains and correlate with the MHC class II genotype. (3)
    
    1. EYLAR, E. H., in L.Rowland (Editor), Immunologic disorders of the nervous system, Academic Press, New York, 1971, Chapter 5.
    2. Jones et al (1992) the synthetic 87-99 peptide of myelin basic protein is encelphalitogenic in Buffalo rats. J.Neuroimmunol. 37 203
    3. Fritz, R., and D.E. McFarlin . 1989. Encephalitogenic epitopes 10. Richert, J., E.D. Robinson, G.E . Deibler, R.E. Martenson, of myelin basic protein. Chem. Immunol. 46:101.
- Properties
  - Categories
    
    Encephalitogenic peptide
    
    Alternative Name
    
    Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro; Myelin Basic Protein (87-99)
    
    CAS Number
    
    118506-26-6
    
    Molecular Formula
    
    C74H114N20O17
    
    Molecular Weight
    
    1555.8
    
    Appearance
    
    A solid
    
    Purity
    
    98.11%
    
    Solubility
    
    ≥15.97 mg/mL in EtOH with gentle warming and ultrasonic; ≥50.7 mg/mL in H2O; ≥77.8 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CCC(C)C(C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)N1CCCC1C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)O)C(=O)N2CCCC2C(=O)O)NC(=O)C(CC(=O)N)NC(=O)C(CCCCN)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC5=CN=CN5)NC(=O)C(C(C)C)N
    
    * For Research Use Only