Name: Mycophenolic Acid
Price: 172.00 USD

- Overview
  - Mycophenolic Acid is an antimetabolite and an active metabolite of Mycophenolate mofetil. It can inhibit DNA synthesis of T and B lymphocytes via selective inhibition of inosine monophosphate dehydrogenase. It also acts as an immunosuppressive agent commonly used solid-organ transplantation. As a selection agent, it is used for transfected animal cells expressing the E. coli gene for xanthine-guanine phosphoribosyl transferase. Mycophenolic Acid is freely soluble in methanol but insoluble in water.
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    Background
    
    Mycophenolic Acid blocks inosine monophosphate dehydrogenase in the guanosine monophosphate pathway and suppresses cytokine-induced nitric oxide production.
- Properties
  - CAS Number
    
    24280-93-1
    
    Molecular Formula
    
    C17H20O6
    
    Molecular Weight
    
    320.34
    
    Appearance
    
    White or off-white powder
    
    Other Properties
    
    Source: Penicillium stoloniferum
    Assay: (On Dried Basis): ≥98.0%
    Residue On Ignition: Not more than 0.1%
    Loss on Drying: Not more than 1.0%
    Melting Point: 138-142°C
    Identification: Conforms
    
    Storage
    
    <30°C
    
    * For research use only
- Applications
  - Application Description
    
    Cancer Applications: Mycophenolic Acid acts as an inhibitor for inosine monophosphate dehydrogenase (IMPDH), an enzyme responsible for controlling the rate of guanine monophosphate synthesis. IMPDH is required for T-cell and B-cell growth and proliferation to a higher degree than other host cells.