Moxalactam (sodium salt)

- Overview
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    Background
    
    Moxalactam (sodium salt) is a β-lactam antibiotic.β-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most β-lactam antibiotics act by inhibiting cell wall biosynthesis. Moxalactam is an oxacephem antibiotic and inhibits most commonly occurring gram positive, gram negative, and anaerobic bacteria. Moxalactam was more active against Klebsiella and E coli than cefoperazone. Moxalactam did not inhibit methicillin-resistant S. aureus and Enterococci. Moxalactam had been extremely active against Haemophilis and Neisseria gonorrhoeae. Moxalactam was extremely resistant to hydrolysis by all plasmid and chromosmal β-lactamases [1]. In certain situations, Moxalactam impaired normal hemostasis and prolonged bleeding time [2].
    
    [1]. Neu HC. The in vitro activity, human pharmacology, and clinical effectiveness of new beta-lactam antibiotics. Annu Rev Pharmacol Toxicol. 1982;22:599-642.
    [2]. Sattler FR, Weitekamp MR, Ballard JO. Potential for bleeding with the new beta-lactam antibiotics. Ann Intern Med. 1986 Dec;105(6):924-31.
- Properties
  - Categories
    
    β-lactam antibiotic
    
    Alternative Name
    
    Antibiotic 6059S,Latamoxef,LY 127935; (6R,7R)-7-[[(2R)-2-carboxy-2-(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, disodium salt
    
    CAS Number
    
    64953-12-4
    
    Molecular Formula
    
    C20H18N6O9S·2Na
    
    Molecular Weight
    
    564.4
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥25.95 mg/mL in DMSO; insoluble in EtOH; ≥62.6 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    OC1=CC=C([[email protected]@H](C([O-])=O)C(N[[email protected]@]2(OC)[[email protected]](OCC(CSC3=NN=NN3C)=C4C([O-])=O)([H])N4C2=O)=O)C=C1.[Na+].[Na+]
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Datasheet

Moxalactam (sodium salt)

Background

Documents

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