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Overview
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Predicted MW: Monomer, 8 kDa (68 aa). Stromal cell-derived factor-1 alpha (SDF-1 alpha), also called CXCL12a, is one of two SDF-1 splice variants made by a wide variety of cells upon stimulation by inflammatory cytokines such as TNF, IL-1, and LPS. SDF-1alpha signals through the G protein-coupled receptor CXCR4 to recruit activated leukocytes. Human and mouse SDF-1 alpha share 99% sequence identity.
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Overview