Mouse / Rat IGF-1 ELISA

Beside different cell culture models and studies with human material, mice and rats are suitable model organisms for basic research and pre-clinical studies. Thus, this test system was developed as a tool for IGF-I measurements in mice and rat for usage in research and pre-clinical studies. Even if the comparability of mice and humans is limited some background information on the human IGF-I system follows:
Insulin-like growth factors (IGF) I and II play a pivotal role in regulating the proliferation, differentiation and specific functions of many cell types. IGF-I is identical with Somatomedin C (Sm-C) and has a molecular weight of 7649 daltons. Its major regulators are growth hormone (GH) and nutrition, although its production in specific tissues is affected by a multitude of tropic hormones and other peptide growth factors. In contrast to many other peptide hormones, IGFs are avidly bound to specific binding proteins (IGFBP).

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