Mosapride Citrate

- Overview
  - Mosapride Citrate, developed by Takeda, is a gastroprokinetic agent that enhances gastrointestinal motility, and exerts anti-inflammatory effects on the GI tract. It acts as a 5-HT4 receptor agonist and 5-HT3 receptor antagonist.
    
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    Background
    
    Mosapride Citrate is a 5-HT4 receptor agonist and 5-HT3 receptor antagonist. It is also used as an antispasmodic.
- Properties
  - Categories
    
    BioActive Small Molecules
    
    CAS Number
    
    112885-42-4
    
    Molecular Formula
    
    C21H25ClFN3O3•C6H8O7
    
    Molecular Weight
    
    614.02
    
    Appearance
    
    white or off-white crystalline powder
    
    Solubility
    
    Very soluble in DMSO
    
    Other Properties
    
    Source: Synthetic
    Purity Level: ≥98.5% (anhydrous basis)
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Eukaryotic Cell Culture Applications: Mosapride Citrate was able to induce the formation of a functional organ-like cluster, a "gut" from mouse embryonic stem cells using an embroid body culture system. If it was added during the formation of the embryoid body at a concentration of 1-10 uM, it induced the formation of this organ-like cluster, which had dense distributions of interstitial cells and smooth muscle cells, and was able to spontaneously contract on its own (Takaki et al 2001). Mosapride Citrate was used in a rapid, high-throughout luminescent screening assay to measure cytochrome P4500 induction. The induction of the isozymes 1A2, 2B6, 2C9, and 3A4 in cryopreserved human hepatocytes (HMC424, 478, and 493). Authors found the compound promoted CYP1A2, 2B6, and 3A4 activities (Kim et al, 2015).