Monazomycin

- Overview
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    Background
    
    Monazomycin is a positively charged and polyenelike antibiotic produced by Streptomyces [1].
    Monazomycin is able to induce a voltage-dependent conductance in lipid bilayer membranes. Monazomycin is selective for monovalent cations and can alter the membrane conductance when applied to one or both sides of the membrane [1]. Application of micromolar amounts of monazomycin on one side of phospholipid bilayer membranes induced dramatic voltage-dependent conductance effects. The steady-state conductance was proportional to the 5th power of the monazomycin concentration and increased exponentially with positive voltage (monazomycin side positive); there was an e-fold change in conductance per 4–6 mv. The major current-carrying ions were univalent cations. Monazomycin monomers cooperated to form a multimolecular conductance channel. The voltage control of conductance arose from the electric field driving monazomycin molecules at the membrane surface into the membrane and thus affecting the number of channels that were formed [2].
    
    [1] Bamberg E, Janko K. Single channel conductance at lipid bilayer membranes in presence of monazomycin[J]. Biochimica et Biophysica Acta (BBA)-Biomembranes, 1976, 426(3): 447-450.
    [2] Muller R U, Finkelstein A. Voltage-dependent conductance induced in thin lipid membranes by monazomycin[J]. The Journal of general physiology, 1972, 60(3): 263-284.
- Properties
  - Categories
    
    macrocyclic polyol lactone that is active against Gram-positive bacteria
    
    Alternative Name
    
    Takacidin,U-0142; 48-(7-amino-1-methylheptyl)-8,10,16,20,24,26,28,32,36,38,40,42,44,46-tetradecahydroxy-23-(α-D-mannopyranosyloxy)-9,15,17,19,21,25,31,33,39,41,47-undecamethyl-oxacyclooctatetraconta-13,17,21,29-tetraen-2-one
    
    CAS Number
    
    11006-31-8
    
    Molecular Formula
    
    C72H133NO22
    
    Molecular Weight
    
    1364.8
    
    Appearance
    
    A solid
    
    Purity
    
    Purity ≥95.00%
    
    Solubility
    
    Soluble in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    OC(CC(C(C(C(O[[email protected]@H]1[[email protected]@H](O)[[email protected]@H](O)[[email protected]](O)C(CO)O1)/C=C(C)/C(O)C(C)/C=C(C)/C(O)C(C)/C=C/CCC(O)C(C)C(O)CCCCCC2=O)O)C)O)/C=C/C(C)C(O)C(C)CCC(O)CC(O)C(C)C(O)C(C)C(O)CC(O)CC(O)C(C)C(O2)C(C)CCCCCCN
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Datasheet

Monazomycin

Background

Documents

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