Molecubes Modular Benchtop Preclinical CT Imaging System

Application objects of Molecubes CT:
(1) in vivo: The research objects are living mice and rats, which can realize the longitudinal study of physiological and metabolic functions. Similar to clinical CT, small animal CT can also perform respiration/heartbeat gated and developer enhanced scanning.
(2) in vitro: The research object is in vitro specimens (such as bone, teeth) or samples of various materials. A coagulated contrast agent can also be used to infuse live animals for fine imaging of the cardiovascular, urinary, or digestive systems.

Main applications of Molecubes CT:
1. Bone: Bone research is one of the most important applications of preclinical CT because of the relatively obvious difference between bone and other body tissues in X-ray attenuation performance. Cortical bone and bone trabecular analysis can be performed, and the changes are associated with conditions such as osteoporosis, fractures, osteoarthritis, ischemia, and genetic diseases, as well as bone tumors.
2. Teeth and periodontal tissues: From the 3D overall structure, root canal morphological changes, dental caries destruction, dental tissue density changes, alveolar bone structure and mechanical properties changes can be studied.
3. Biomaterials: Analyze the porosity, strength and other parameters of biomimetic materials prepared in vitro; Scan tissue samples that need to be replaced to obtain three-dimensional images; Imaging analysis of medical device materials, such as heart stents, cerebrovascular stents, etc. Implant compatibility analysis; Let's wait.
4. Disease Detection and Research:
(1) Oncology research: It can study the occurrence and treatment evaluation of lung tumors, brain tumors and parenteral tumors; CT can detect the nature of the tumor, such as the growth form of the tumor, the degree of invasive growth, and whether the surrounding boundary is clear and whether there is a complete envelope.
(2) Bone research: Study the influence of different genes or signaling pathways on the quantity or quality of bone, the influence of disease states on bone development/repair, the influence of cytokines on blood vessel growth during tissue repair after fracture, etc.
(3) Brain research: It is mainly used to diagnose cerebral vascular lesions and intracranial hemorrhage, and the examination does not necessarily need to use a developer. In the case of acute stroke, the possibility of bleeding can be ruled out. In addition, it is also very useful in the diagnosis of skull and facial bone fractures with trauma.
(4) Lung research: In the diagnosis of lung tissue, there is a high diagnostic value for acute or chronic changes, such as pneumonia or tumors. Some interstitial tissue changes (lung parenchyma, lung fibers, etc.) can be reconstructed with high resolution Settings of thin sections.
(5) Angiography: The developer is rapidly injected into the heart cavity or blood vessel through the cardiac catheter, so that the heart and blood vessel cavity can be developed under CT irradiation. Using contrast media CT, the vascular system and blood-rich tissues and organs can be shown. Ranging from arteries to heart, lungs, kidneys, liver, etc. Provides a better soft tissue contrast for sharper imaging.
(6) Heart research: The data of cardiac tomography can be combined with gated observation of the heart beat to reduce the moving false image caused by high-speed heartbeat, and can also preliminarily check the health status of the heart muscle.
(7) Analysis of body fat distribution: study the distribution rule of adipose tissue, redistribution under certain pathological conditions (such as Cushing syndrome, etc.), the relationship between obesity and metabolism-endocrine disorders and cardiovascular system complications.
(8) Inflammation, calcification (to evaluate the effect of hyperlipidemia on heart valve calcification), stones.
(9) Nanotracers: Research on applications related to novel nanotracers in the fields of urology, thyroid, and oncology, especially the transport mechanisms of nanoparticles, such as the different transport processes and distribution characteristics of gold nanoparticles metabolized by the kidney in normal and injured kidneys.
5. New drug development: research on new osteoporosis drugs and efficacy evaluation, etc.
6. auxiliary positioning: combined with preclinical PET, SPECT, or with small animal live optical imaging, can be used for structural imaging, auxiliary positioning.
7. Others: Structural detection of other organic or inorganic materials, quality inspection and flaw detection of micro-devices, fossil structure analysis, etc.