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ML133 HCl

ML133 HCl

Catalog Number:

L002370359APE

Mfr. No.:

APE-B2199

Price:

$145

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- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    ML133 is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1.
- Properties
  - Alternative Name
    
    1-(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine;hydrochloride
    
    CAS Number
    
    1222781-70-5
    
    Molecular Formula
    
    C19H19NO·HCl
    
    Molecular Weight
    
    313.82
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; ≥15.7 mg/mL in DMSO; ≥2.52 mg/mL in EtOH with gentle warming and ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    COC1=CC=C(C=C1)CNCC2=CC=CC3=CC=CC=C32.Cl
    
    * For Research Use Only
- Reference
  - 1. NAN CAO, NIGALA AIKEREMU, et al. "Inhibition of KIR2. 1 decreases pulmonary artery smooth muscle cell proliferation and migration." Int J Mol Med. 2022 Sep;50(3):119. PMID: 35856410

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