Name: ML-354
Price: 254.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    IC50: 140 nM
    ML-354 is an indole-based, proteinase-activated receptor (PAR) 4 antagonist with good potency and reasonable selectivity versus PAR1. PARs are a family of four G-protein-coupled receptors GPCRs (PAR1-PAR4) with several unique attributes, which are activated by serine proteases. The activation of PARs needs a unique mechanism which requiring proteolysis unmasking their extracellular N-terminal domain. PAR4 is a thrombin receptor found on human platelets and represents a potential therapeutic target for the treatment of thrombotic disorders [1].
    In vitro: Up to now, in vitro study of ML-354 is still in the development stage.
    In vivo: Up to now, in vivo study of ML-354 is still in the development stage.
- Properties
  - Categories
    
    PAR4 antagonist
    
    Alternative Name
    
    VU0099704; 1-methyl-5-nitro-3-phenyl-1H-indole-2-methanol
    
    CAS Number
    
    89159-60-4
    
    Molecular Formula
    
    C16H14N2O3
    
    Molecular Weight
    
    282.3
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    Purity ≥95.00%
    
    Solubility
    
    ≤2mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CN1C(CO)=C(C2=CC=CC=C2)C3=C1C=CC([N+]([O-])=O)=C3
    
    * For Research Use Only