ML 228

ML 228

Catalog Number:
FC01364956APE
Mfr. No.:
APE-A4508
Price:
$326
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      • Overview
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          Background

          HIF pathway activator (EC50 values are 1.23 and 1.4 μM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively); acts via chelation of iron, independently of PHD. Also exhibits > 80% inhibition of the human A3 receptor, dopamine transporter, μ receptor, hERG and 5-HT2B receptor, and rat sodium channel site 2, at a concentration of 10 μM.

      • Properties
        • Categories
          HIF pathway activator
          Alternative Name
          N-([1,1'-biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine
          CAS Number
          1357171-62-0
          Molecular Formula
          C27H21N5
          Molecular Weight
          415.49
          Appearance
          A crystalline solid
          Purity
          98.00%
          Solubility
          Soluble in DMSO
          Storage
          Store at -20°C
          SMILES
          C1(C2=NC=CC=C2)=NC(NCC3=CC=C(C4=CC=CC=C4)C=C3)=C(C5=CC=CC=C5)N=N1

          * For Research Use Only

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