Mitochondrial Complex I Activity Colorimetric Assay (TBS2017)

Mitochondrial Complex I or NADH: ubiquinone oxidoreductase is the first and the largest complex of the electron transport chain located in the mitochondrial membrane. It oxidizes NADH to NAD+ and transfers an electron to ubiquinone (also present in the inner mitochondrial membrane) converting it to ubiquinol. During this process, it transports protons across the inner mitochondrial membrane, helping to develop an electrochemical gradient. This process is very important for cellular respiration and adverse effects on Complex I activity can compromise mitochondrial respiration, which further leads to cellular stress.

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