Name: Midecamycin
Price: 269.00 USD

- Overview
  - Midecamycin is an naturally occurring, broad-spectrum acetoxy-substituted macrolide antibiotic similar in structure to erythromycin. An acetoxy group is substituted on position 9 of the 16-membered ring and on position 4 of the terminal sugar. It is naturally produced by Streptomyces mycarofaciens. It interrupts protein synthesis of Gram-positive and Gram-negative bacteria. Its metabolites present little to no antimicrobial activity. It is very soluble in methanol, ethanol, and acidic solutions and soluble in DMSO.
    
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    Background
    
    Midecamycin inhibits bacterial growth by targeting the 50S ribosomal subunit preventing peptide bond formation and translocation during protein synthesis. Resistance to Midecamycin is commonly attributed to mutations in 50S rRNA preventing Midecamycin binding allowing the cell to synthesize proteins free of error.
- Properties
  - CAS Number
    
    35457-80-8
    
    Molecular Formula
    
    C41H67NO15
    
    Molecular Weight
    
    813.97
    
    Appearance
    
    White or off-white powder
    
    Other Properties
    
    Source: Streptomyces mycarofaciens
    Residue On Ignition: ≤0.2%
    Heavy Metals: ≤20ppm
    Loss on Drying: ≤1.0%
    Melting Point: 153-158°C
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Midecamycin is a broad-spectrum antibiotic targeting a wide range of Gram-positive and Gram-negative bacteria especially those which cause respiratory, ear, and skin infections. It is active against Streptococci, Staphylococci, Corynebacterium diphtheriae, and Bordetella pertussis.
    
    Eukaryotic Cell Culture Applications: In vitro research of Midecamycin showed immunosuppressive properties by inhibiting T-cell responses via suppressing IL-2. These results suggest potential application for post-transplant complications and inflammatory diseases.