MI-nc (hydrochloride)

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    MI-nc is a weak inhibitor of the menin-MLL fusion protein interaction with an IC50 of 193 μM. It can be used as a negative control compound for tests involving MI-2, which showed more binding potency with menin, blocked the menin-MLL interaction with an IC50 of 0.45 μM, and induced apoptosis in cells expressing MLL fusion proteins [1]. Menin, a product of the multiple endocrine neoplasia gene, is an essential co-factor of oncogenic MLL fusion proteins. MLL interacts with menin in a bivalent mode involving 2 N-terminal fragments of MLL, and the menin–MLL interaction is critical for development of acute leukemia. Inhibition of the menin interaction with MLL fusion proteins is a very promising strategy to reverse their oncogenic activity [2].
    
    [1]. Grembecka J, He S, Shi A, et al. Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia[J]. Nature chemical biology, 2012, 8(3): 277-284.
    [2]. Yokoyama A, Somervaille T C P, Smith K S, et al. The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis[J]. Cell, 2005, 123(2): 207-218.
- Properties
  - Alternative Name
    
    6-ethyl-4-[4-(1,3,4-thiadiazol-2-yl)-1-piperazinyl]-thieno[2,3-d]pyrimidine, dihydrochloride
    
    CAS Number
    
    1934302-23-4
    
    Molecular Formula
    
    C14H16N6S2·2HCl
    
    Molecular Weight
    
    405.4
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≤0.1mg/ml in ethanol;1.3mg/ml in DMSO;0.5mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

MI-nc (hydrochloride)

Background

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