Name: Mevastatin
Price: 188.00 USD

- Overview
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    Background
    
    Mevastatin is an inhibitor of HMG-CoA reductase with Ki value of 1nM [1].Mevastatin inhibits HMG-CoA reductase reversibly and competes with HMG-CoA. It shows a Ki value of about 1nM. Mevastatin inhibits sterol synthesis from acetate in various cells at low concentration of nanomolar. It also inhibits acetate incorporation with IC50 value of 1nM. Besides that, mevastatin completely suppresses the growth of L cells at 1.3μM. Mevastatin is also found to affect the cell cycle and change cell morphology in cultured fibroblasts [1]. In rats, administration of mevastatin inhibits sterol synthesis in the liver and reduces plasma cholesterol levels. In patients with familial hypercholesterolemia, mevastatin also shows potent effects on reducing plasma cholesterol. Mevastatin at dose of 50 mg/day reduces 25% total cholesterol in a FH heterozygote patient treated with 2 months [1].
    
    [1] Endo A. The discovery and development of HMG-CoA reductase inhibitors. Journal of lipid research, 1992, 33(11): 1569-1582.
- Properties
  - Alternative Name
    
    [(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
    
    CAS Number
    
    73573-88-3
    
    Molecular Formula
    
    C23H34O5
    
    Molecular Weight
    
    390.51
    
    Appearance
    
    A solid
    
    Purity
    
    98.71%
    
    Solubility
    
    insoluble in H2O; ≥15.95 mg/mL in DMSO; ≥3.29 mg/mL in EtOH
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only