Metoclopramide

- Overview
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    Background
    
    Metoclopramide is a dopamine receptor antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is the antiemetic drug of choice in pregnant women. Findings provide reassurance regarding the safety of metoclopramide for the fetus when the drug is given to women to relieve nausea and vomiting during pregnancy. Evidence also supports its use for gastroparesis (poor stomach emptying) and gastroesophageal reflux disease. It appears to bind to dopamine D2 receptors where it is a receptor antagonist, and is also a mixed 5-HT3 receptor antagonist/ 5-HT4 receptor agonist.
- Properties
  - Categories
    
    Dopamine receptor antagonist
    
    Alternative Name
    
    4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide
    
    CAS Number
    
    364-62-5
    
    Molecular Formula
    
    C14H22ClN3O2
    
    Molecular Weight
    
    299.8
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; ≥14.99 mg/mL in DMSO; ≥24.6 mg/mL in EtOH with gentle warming
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl
    
    * For Research Use Only