Methionine choline deficiency diet (MCD)

MCD is a kind of amino acid feed widely used in nonalcoholic fatty liver model of rats and mice. Due to the lack of choline and methionine that can be converted into choline in the feed, the fat in the liver can not be normally transported to the blood, so it accumulates in the liver cells and intercellular spaces to form lipid droplets, and then forms fatty liver. MCD induced nonalcoholic fatty liver has the characteristics of rapid modeling and powerful effect. It can form obvious fatty liver complicated with hepatitis within 5 weeks, and then continue to use it to form liver fibrosis and cirrhosis. Its disadvantage is the lack of methionine. As an essential amino acid, it can not synthesize protein without methionine. Animals will gradually lose weight, become worse and die slowly. MCD is often used to induce acute nonalcoholic fatty liver. Its control feed is methionine choline sufficient feed MCS.
(Small knowledge: amino acid feed is characterized by using various amino acids to replace casein in conventional feed to supply proteins required by organisms, so as to achieve accurate control of the level of one or more amino acids)

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