Name: Meropenem trihydrate
Price: 204.00 USD

- Overview
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    Background
    
    Meropenem trihydrate (SM-7338) is an active ingredient carbapenem antibiotic [1].Meropenem trihydrate has shown the potent effect against gram-negative organisms with the MIC90 values of 0.03μM, 0.06μM, 0.06μM, 0.12μM,0.25μM, 0.12μM, 0.06μM, 0.12μM and 0.25μM for Escherichia coli (30), Klebsiella pneumonia(29), Klebsiella oxytoca (20), Enterobacter aerogenes (14), Enterobacter cloacae (29), Citrobacter freundii (20), Citrobacter diversus (12), proteus mirabilis (15) and Morganella morganii (15), respectively. In addition, Meropenem trihydrate has also been revealed to restrain gram-positive and anaerobic organisms with the MIC90 values of 0.008μM, 4μM and 0.015μM for Streptococcus pyogenes (20), Viridans group streptococci (27), Streptococcus pneumonia (15), respectively. Furthermore, Meropenem trihydrate has shown the different effect of pH on MIC, for example, the mean MIC values of 0.06μM and 0.03μM in pH5.5 and pH7.5, respectively [1].
    
    [1] Neu HC1, Novelli A, Chin NX.In vitro activity and beta-lactamase stability of a new carbapenem, SM-7338.Antimicrob Agents Chemother. 1989 Jul; 33(7):1009-18.
- Properties
  - Categories
    
    Broad-spectum β-lactam antibiotic
    
    Alternative Name
    
    (4R,5S,6S)-3-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;trihydrate
    
    CAS Number
    
    119478-56-7
    
    Molecular Formula
    
    C17H31N3O8S
    
    Molecular Weight
    
    437.51
    
    Appearance
    
    A solid
    
    Purity
    
    98.88%
    
    Solubility
    
    ≥20.7 mg/mL in H2O with gentle warming; insoluble in EtOH; ≥49.2 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC1C2C(C(=O)N2C(=C1SC3CC(NC3)C(=O)N(C)C)C(=O)O)C(C)O.O.O.O
    
    * For Research Use Only