Name: Memantine hydrochloride
Price: 188.00 USD

- Overview
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    Background
    
    Memantine hydrochloride is an antagonist of NMDA receptor with IC50 values of 0.93μM, 0.82μM and 0.47μM for NRIa/NR2A, NRIa/NR2B and NRIa/NR2D, respectively [1].
    Memantine is an uncompetitive NMDA receptor antagonist. When using HEK293 cells express recombinant rat NMDA receptors, memantine shows inhibition of L-glutamate-mediated response with a dose- and voltage-dependent manner. Memantine also has a rapid unblocking kinetics [1].
    Memantine is used clinically in spasticity, Parkinson's disease and Alzheimer’s disease. Memantine is found to attenuate the deleterious action of Aβ in the in vitro numerous studies. It is probably due to the decreased tau phosphorylation caused by memantine [2].
    
    [1] Bresink I, Benke T A, Collett V J, et al. Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cells. British journal of pharmacology, 1996, 119(2): 195-204.
    [2] Danysz W, Parsons C G. Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine–searching for the connections. British journal of pharmacology, 2012, 167(2): 324-352.
- Properties
  - Categories
    
    NMDA receptor antagonist
    
    Alternative Name
    
    3,5-dimethyladamantan-1-amine;hydrochloride
    
    CAS Number
    
    41100-52-1
    
    Molecular Formula
    
    C12H22ClN
    
    Molecular Weight
    
    215.76
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥12.59 mg/mL in DMSO; ≥2.46 mg/mL in EtOH; ≥9.4 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC12CC3CC(C1)(CC(C3)(C2)N)C.Cl
    
    * For Research Use Only