Medium Spiny GABAergic Neurons

Two sizes: 2M Viable Cells/Vial; 1M Viable Cells/Vial

Contents: 1 vial of cells and corresponding supplements

Cryopreserved

Marker Expression and Morphology: Cortical Astrocytes (BX-0600) express key astrocyte markers GFAP (green) and S100β (red) at >90% and exhibit mature process-bearing morphologies (shown here with a DAPI stain).

Calcium Influx Assays:
Changes in calcium concentration are closely tied to neuronal activity as action potentials are associated with large pre-synaptic calcium influx and a notable rise in postsynaptic calcium at excitatory synapses. This can be observed experimentally by stimulating the neurons or culturing the neurons under suitable conditions to form mature networks that exhibit spontaneous oscillations. The influx of calcium can be measured using a variety of calcium-sensitive fluorescent dyes, which are commercially available.

MEA Assays:
Multi-electrode arrays (MEA) measure extracellular voltage changes that occur as neurons fire action potentials. These measurements reveal the firing patterns of individual neurons as well as the patterns of neuronal networks that exist in the cell culture. Such measurements are non-invasive and allow for repeated recordings.

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