Name: MC1568
Price: 188.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    MC1568, a derivative of (Aryloxopropenyl)pyrrolyl hydroxyamide, is a novel, potent and specific inhibitor of class II histone deacetylase (HDAC), including two subclasses IIa (HDAC4, HDAC5, HDAC6, HDAC7 and HDAC9) and IIb (HDAC6 and HDAC 10), that exhibits strong inhibition against maize class II HDAC with 50% inhibition concentration IC50 value of 22 μM. MC1568 has been found to tissue-selectively inhibits HDAC and arrest myogenesis in cultured muscle cells through three possible mechanisms, including decreasing the expression of myocyte enhancer factor 2D, stabilizing the HDAC-HDAC3-MEF2D complex and inhibiting the acetylation of differentiation-induced MEF2D. Moreover, MC1568 is able to interfere with RAR- and PPARγ-mediated differentiation-inducing signaling pathways.
- Properties
  - Alternative Name
    
    MC 1568, MC-1568; (E)-3-[4-[(E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl]-1-methylpyrrol-2-yl]-N-hydroxyprop-2-enamide
    
    CAS Number
    
    852475-26-4
    
    Molecular Formula
    
    C17H15FN2O3
    
    Molecular Weight
    
    314.31
    
    Purity
    
    98.50%
    
    Solubility
    
    insoluble in EtOH; insoluble in H2O; ≥15.7 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Hari Prasad, Rajini Rao. "The Amyloid Clearance Defect in ApoE4 Astrocytes is Corrected by Epigenetic Restoration of NHE6." bioRxiv. 2018.January. 4
    2. Griffin EA Jr, Melas PA, et al. "Prior alcohol use enhances vulnerability to compulsive cocaine self-administration by promoting degradation of HDAC4 and HDAC5." Sci Adv. 2017 Nov 1;3(11):e1701682. PMID:29109977
    3. Ha, Soon-Duck, et al. "Inhibition of IL-1β Expression by Anthrax Lethal Toxin is Reversed by HDAC8 Inhibition in Murine Macrophages." Journal of Biological Chemistry (2016): jbc-M115. PMID:26912657

MC1568

MC1568

Background

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