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Overview
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Mannosamine (Man, 2-Amino-2-Deoxymannose) has the axial hydroxyl group at position 2 replaced by an amino group (Collins, 2006). Mannosamine has importance in the biosynthesis of sialic acids as they are synthesized by the condensation of D-mannosamine with pyruvic acid. Mannosamine has been found to have antitumor activity on human leukemia T-cell lines (Onoda, 1985). Mannosamine was also reported to inhibit glycosylphosphatidylinositol (GPI) synthesis in trypanosomes (Eckert, 1999).
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