m-dPEG®₁₂-MAL

m-dPEG®12-MAL, product number 10289, is a sulfhydryl-reactive, single molecular weight, with a discrete chain length PEG (dPEG®). This product modifies surfaces and biomolecules with free thiol groups through the maleimide reactive group. The non-immunogenic, methyl-terminated dPEG® chain has no charge but adds water solubility and hydrodynamic volume to molecules to which it is conjugated.

PEGylation with dPEG® Products
PEGylation is the process of adding polyethylene glycol to a molecule or a surface. PEGylated surfaces include metal, silica, carbon (nanotube, nanosphere, graphene, diamond), liposomes, micelles, and glass. Conventional PEGylation reagents are non-uniform (that is, disperse) polymers. Any given traditional PEG product consists of an intractable mixture of different chain lengths of PEG. Each different PEG chain has a different molecular weight. The analytical challenges that arise from using dispersed polymers are complex and possibly impenetrable.

Oursingle molecular weight dPEG® products are different from traditional PEG products. Because they are synthesized from high-purity starting materials, our dPEG® products have no dispersity and are like small molecules. With each dPEG® products, there is only one molecular weight and one chain length of PEG. Hence, the PEG products are discrete, which is why we sell them under the dPEG® tradename.

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