Name: LY2608204
Price: 349.00 USD

- Overview
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    Background
    
    LY2608204 is a novel and potent activates of glucokinase (GK) with the EC50 value of 42nM [1].LY2608204 has shown the novel and potent stimulant of glucokinase (GK) with the EC50 value of 42nM at lower glucose concentrations. In addition, LY2608204 has been reported to activate glucose metabolism with the EC50 value of 579nM in rat insulinoma INS1-E cell lines. Apart from these, LY2608204 has been revealed to lower plasma glucose in a dose-dependent fashion at the levels of fasted and postprandial [1].
    
    [1] KJ Filipski, BD Stevens . Glucokinase activators in development .2012 books
- Properties
  - Categories
    
    GK activator
    
    Alternative Name
    
    (1R,2S)-2-cyclohexyl-1-(4-cyclopropylsulfonylphenyl)-N-[5-(2-pyrrolidin-1-ylethylsulfanyl)-1,3-thiazol-2-yl]cyclopropane-1-carboxamide
    
    CAS Number
    
    1234703-40-2
    
    Molecular Formula
    
    C28H37N3O3S3
    
    Molecular Weight
    
    559.81
    
    Appearance
    
    A solid
    
    Purity
    
    99.19%
    
    Solubility
    
    ≥28.35 mg/mL in DMSO; insoluble in H2O; ≥26.2 mg/mL in EtOH
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    C1CCC(CC1)C2CC2(C3=CC=C(C=C3)S(=O)(=O)C4CC4)C(=O)NC5=NC=C(S5)SCCN6CCCC6
    
    * For Research Use Only