Lipoamido-dPEG®₂₄-TFP ester

Lipoamido-dPEG®24-TFP ester, product number 10643, is a monodispersed, crosslinking PEGylation reagent that joins free amines to metal surfaces. The single molecular weight, discrete-chain-length polyethylene glycol (dPEG®) product consists of alpha-lipoic acid and a 2,3,5,6-tetrafluorophenol (TFP) ester on opposite ends of a dPEG® spacer. The lipoic acid group forms two (2) coordinate covalent bonds (dative bonds) with metal, especially gold and silver. The TFP ester reacts with free amines to form amide bonds. Applications for this product include peptide or protein immobilization on metal surfaces, the formation of self-assembled monolayers (SAMs) on metal surfaces, and sensor development.

What is the dPEG® difference?
Traditional PEGylation reagents are dispersed (non-uniform) polymers. These products consist of a broad range of PEG chain lengths and molecular weights in a Poisson distribution. This mixture of different PEG products adds analytical complexity (and, hence, time and money) to the characterization of conjugates made with traditional PEG polymers.

In contrast, our dPEG® products are single molecular weight PEGs with discrete chain lengths. Each dPEG® product consists of one PEG molecular weight and chain length. We synthesize all of our dPEG® products from high purity starting materials using proprietary processes that assure the highest quality reagents for your work. The single molecular weight and discrete chain length of our products reduce the analytical complexity of conjugates made with dPEG® reagents, thus saving time and money. In other words, our customers gain all of the benefits of PEG without the headaches that come with using dispersed polymers. We call these benefits, "the dPEG® difference."

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