Leucomycin A1

- Overview
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    Background
    
    Leucomycin A1, a major metabolite extracted from the leucomycin complex, is a major macrocyclic lactone antibiotics produced by Streptomyces kitasatoensis. Leucomycin A1 is one of the more potent members of leucomycin complex. Leucomycin complex (kitasamycin) is effective against a wide spectrum of pathogens, such as Gram-positive bacteria, Gram-negative cocci, mycoplasma, and Leptospira. Leucomycin complex has been used as an animal health product for control of Gram positive bacteria, Gram negative cocci, mycoplasma, and Leptospira. Until now, little is known about the activity of individual analogues within the complex. At a concentration of 1.56μg/ml, kitasamycin inhibited all isolates of Diplococcus pneumonia [2]. Each component of leucomycins potently inhibited the growth of Gram-positive bacteria and showed not so strong activity against the Gram-negative bacteria. Each component showed the same tendency towards the antibacterial spectrum [3].
    
    [1] Hata T, Sano Y, Ohki N, et al. Leucomycin, a new antibiotic[J]. The Journal of antibiotics, 1953, 6(2): 87-89.
    [2] Balducci Y, BODEY G P. In vitro activity of kitasamycin against gram-positive cocci[J]. The Journal of antibiotics, 1974, 27(7): 516-519.
    [3] Omura S, Katagiri M, Umezawa I, et al. Structure-biological activities relationships among leucomycins and their derivatives[J]. The Journal of antibiotics, 1968, 21(9): 532-538.
- Properties
  - Categories
    
    major metabolite of macrolide antibiotics
    
    Alternative Name
    
    Kitasamycin A1,3-deacetyl Josamycin,Leucomycin V 4-isovalerate,9-dihydro Niddamycin,Turimycin H5; 4B-(3-methylbutanoate) leucomycin V
    
    CAS Number
    
    16846-34-7
    
    Molecular Formula
    
    C40H67NO14
    
    Molecular Weight
    
    786.0
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    Soluble in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O=C1C[[email protected]]([[email protected]@H]([[email protected]]([[email protected]](C[[email protected]]([[email protected]](/C=C/C=C/C[[email protected]](O1)C)O)C)CC=O)O[[email protected]@]2(O[[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]]2O)N(C)C)O[[email protected]]3(C[[email protected]@](O)([[email protected]]([[email protected]@H](O3)C)OC(CC(C)C)=O)C)[H])C)[H])OC)O
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Datasheet

Leucomycin A1

Background

Documents

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