Lestaurtinib

Lestaurtinib

Catalog Number:
L002369268APE
Mfr. No.:
APE-A4513
Price:
$490
  • Size:
    1mg
    Quantity:
    Add to Cart:
      • Overview
        • Please contact us at for specific academic pricing.

          Background

          Potent JAK2, FLT3 and TrkA inhibitor (IC50 values are 0.9, 3 and < 25 nM respectively) that prevents STAT5 phosphorylation (IC50 = 20 - 30 nM). Exhibits antiproliferative activity in vitro (IC50 = 30 - 100 nM in HEL92.1.7 cells) and is effective against myeloproliferative disorders in vivo.

      • Properties
        • Alternative Name
          (5S,6S,8R)-6-hydroxy-6-(hydroxymethyl)-5-methyl-7,8,14,15-tetrahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacen-13(6H)-one
          CAS Number
          111358-88-4
          Molecular Formula
          C25H21N3O4
          Molecular Weight
          439.46
          Appearance
          A crystalline solid
          Purity
          98.00%
          Solubility
          Soluble in DMSO
          Storage
          Desiccate at -20°C

          * For Research Use Only

      • Reference
        • 1. Lin M, Chen B. "Advances in the drug therapies of acute myeloid leukemia (except acute wpromyelocytic leukemia)." Drug Des Devel Ther. 2018 Apr 30;12:1009-1017. PMID:29750014

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