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Overview
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Leptomycin A is an antifungal and methyl analog of Leptomycin B, is a minor component of the Leptomycin complex produced by selected Streptomyces species. Leptomycin A, like Leptomycin B, is a potent inhibitor of the nuclear transport receptor exportin 1 (CRM1). The two may differ in exporter selectivity. The compound is less potent than its analog, Leptomycin B. Leptomycin A has antimicrobial activity against Schizosaccaromyces pombe and Mucor rouxianus.
Leptomycin A is soluble in ethanol and methanol, practically insoluble in water, and unstable in DMSO.Please contact us at for specific academic pricing.
Background
Leptomycin A inhibits CRM1 (exportin 1), a nuclear export inhibitor, preventing the nuclear export of a broad range of proteins. It suppresses HIV-1 replication.
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Overview
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