Lentiviral human IGF2R sgRNA gene knockout kit

Human IGF2R

Gene symbol: IGF2R
Synonyms: CD222 CI-M6PR CIMPR M6P-R M6P/IGF2R MPR 300 MPR1 MPR300 MPRI
Species: HUMAN
Gene ID: 3482
Summary: This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_000876:19:19