Lentiviral human GRM7 sgRNA gene knockout kit

Human GRM7

Gene symbol: GRM7
Synonyms: GLUR7 GPRC1G MGLU7 MGLUR7 PPP1R87
Species: HUMAN
Gene ID: 2917
Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_000844:2:2 NM_181874:2:2