Lentiviral human GRB10 sgRNA gene knockout kit

Lentiviral human GRB10 sgRNA gene knockout kit

Catalog Number:
CGKK543606FEN
Mfr. No.:
HKO-613704
Price:
$878
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      • Overview
        • Kit Components: Lentiviral particles or plasmids for a set of three sgRNAs, and a pair of Indel screening PCR primers

          sgRNA lentiviral particle information
          • Functional titer: 1x10^8 TU/ml
          • Titration method: counting puromycin resistant cell clones
          • Purity: In vivo grade
          • Pseudotype: VSVG
          • Storage buffer: LentiShield™ lentivirus storage buffer
          • Storage: condition -80°C
          • Availability: 3-5 weeks

          sgRNA lentiviral plasmid information
          • Promoter for target sgRNA: U6
          • Mammalian selection: puromycin
          • Promoter for mammalian selection gene: EF1a
          • E.coli selection: Amp
          • Storage condition: -20°C
          • Availability: 1-2 weeks

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          Target Information

          Target Name
          Human GRB10
          About Target
          Gene symbol: GRB10
          Synonyms: Grb-10 GRB-IR IRBP MEG1 RSS
          Species: HUMAN
          Gene ID: 2887
          Summary: The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010].
          NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001350814:8:5 NM_001001549:5:5 NM_001001550:5:3 NM_001001555:6:3 NM_001350815:5:5 NM_001350816:7:3 NM_001371008:5:3 NM_001371009:5:5
      • Properties
        • * For Research Use Only.

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