Lentiviral human GPI sgRNA gene knockout kit

Human GPI

Gene symbol: GPI
Synonyms: AMF GNPI NLK PGI PHI SA-36 SA36
Species: HUMAN
Gene ID: 2821
Summary: This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001184722:6:6 NM_001289789:7:7 NM_001289790:5:5 NM_000175:6:6 NM_001329909:7:6 NM_001329910:7:6 NM_001329911:6:6