Lentiviral human GPER1 sgRNA gene knockout kit

Human GPER1

Gene symbol: GPER1
Synonyms: CEPR CMKRL2 DRY12 FEG-1 GPCR-Br GPER GPR30 LERGU LERGU2 LyGPR mER
Species: HUMAN
Gene ID: 2852
Summary: This gene encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum and a member of the G-protein coupled receptor 1 family. This receptor binds estrogen and activates multiple downstream signaling pathways, leading to stimulation of adenylate cyclase and an increase in cyclic AMP levels, while also promoting intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. This receptor has been shown to play a role in diverse biological processes, including bone and nervous system development, metabolism, cognition, male fertility and uterine function. [provided by RefSeq, Aug 2017].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001505:2:1 NM_001039966:3:1 NM_001098201:2:1