Lentiviral human GABRA1 sgRNA gene knockout kit

Human GABRA1

Gene symbol: GABRA1
Synonyms: ECA4 EIEE19 EJM EJM5
Species: HUMAN
Gene ID: 2554
Summary: This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_000806:8:6 NM_001127643:8:6 NM_001127644:7:6 NM_001127645:7:6 NM_001127648:6:6