Lentiviral human FGFR4 sgRNA gene knockout kit

Human FGFR4

Gene symbol: FGFR4
Synonyms: CD334 JTK2 TKF
Species: HUMAN
Gene ID: 2264
Summary: The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_002011:3:2 NM_022963:2:2 NM_213647:3:2 NM_001291980:3:2 NM_001354984:3:2