Lentiviral human FGFR1OP sgRNA gene knockout kit

Human FGFR1OP

Gene symbol: FGFR1OP
Synonyms: FOP
Species: HUMAN
Gene ID: 11116
Summary: This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_007045:5:5 NM_194429:5:5 NM_001278690:5:5