Lentiviral human ERCC6 sgRNA gene knockout kit

Human ERCC6

Gene symbol: ERCC6
Synonyms: ARMD5 CKN2 COFS COFS1 CSB CSB-PGBD3 POF11 RAD26 UVSS1
Species: HUMAN
Gene ID: 2074
Summary: This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The encoded protein has ATP-stimulated ATPase activity, interacts with several transcription and excision repair proteins, and may promote complex formation at DNA repair sites. Mutations in this gene are associated with Cockayne syndrome type B and cerebrooculofacioskeletal syndrome 1. Alternative splicing occurs between a splice site from exon 5 of this gene to the 3' splice site upstream of the open reading frame (ORF) of the adjacent gene, piggyback-derived-3 (GeneID:267004), which activates the alternative polyadenylation site downstream of the piggyback-derived-3 ORF. The resulting transcripts encode a fusion protein that shares sequence with the product of each individual gene. [provided by RefSeq, Mar 2016].
NM numbers targeted (Accession number:Exon:CDS Fragment): NM_001277058:2:1 NM_001277059:2:1 NM_000124:2:1 NM_001346440:2:1